Ofev 150 mg (Nintedanib 150 mg Capsules)

Ofev contains nintedanib, used to slow the progression of fibrotic lung diseases such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc‑ILD)

 Indications:

• Slows lung function decline in idiopathic pulmonary fibrosis (IPF)

• Treats progressive fibrosing ILD in systemic sclerosis or other fibrosing lung disorders

 Warnings & Precautions:

• Must be used under specialized medical supervision.

• Contraindicated during pregnancy; effective contraception required during treatment and for 3 months after last dose

• Regular monitoring of liver enzymes, blood pressure, and cardiovascular risk is essential. Caution in patients with heart disease, clotting history, or bleeding tendency

 Side Effects:

• Common: diarrhea, nausea, vomiting, abdominal pain, decreased appetite, headache, weight loss, hypertension

• Serious: liver enzyme elevation, jaundice, arterial thrombosis (stroke, myocardial infarction), GI perforation, proteinuria, bleeding events

Therapy interruption or dose reduction is advised for severe or persistent GI symptoms

 Administration:

• Oral capsules, 150 mg twice daily with food and water, spaced about 12 hours apart.

• Dose can be reduced to 100 mg twice daily if not tolerated.

• Swallow whole; do not open or crush capsules. Wash hands thoroughly after handling

Storage:

• Store at room temperature below 30°C, in a dry place away from heat.

• Keep out of reach of children.

• Do not use after expiration date

• dispensed from el-senorsy pharmacy fayoum Egypt